Expression Signatures of Metastatic Capacity in a Genetic Mouse Model of Lung Adenocarcinoma

@article{Gibbons2009ExpressionSO,
  title={Expression Signatures of Metastatic Capacity in a Genetic Mouse Model of Lung Adenocarcinoma},
  author={Don L. Gibbons and Wei Ju Lin and Chad J Creighton and Shuling Zheng and Dror Berel and Yanan Yang and Maria Gabriela Raso and Diane D. Liu and Ignacio Wistuba and Guillermina Lozano and Jonathan M. Kurie},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={3249 - 3262}
}
BACKGROUND Non-small cell lung cancer (NSCLC) is the foremost cause of cancer-related death in Western countries, which is due partly to the propensity of NSCLC cells to metastasize. The biologic basis for NSCLC metastasis is not well understood. METHODOLOGY/PRINCIPAL FINDINGS Here we addressed this deficiency by transcriptionally profiling tumors from a genetic mouse model of human lung adenocarcinoma that develops metastatic disease owing to the expression of K-ras(G12D) and p53(R172H). We… CONTINUE READING

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target predictions

  • CJ Creighton, A Casa, Z Lazard, S Huang, A Tsimelzon
  • 2008

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