Expression Levels of pvcrt-o and pvmdr-1 Are Associated with Chloroquine Resistance and Severe Plasmodium vivax Malaria in Patients of the Brazilian Amazon

@inproceedings{Melo2014ExpressionLO,
  title={Expression Levels of pvcrt-o and pvmdr-1 Are Associated with Chloroquine Resistance and Severe Plasmodium vivax Malaria in Patients of the Brazilian Amazon},
  author={Gisely Cardoso de Melo and Wuelton Marcelo Monteiro and Andr{\'e} Machado Siqueira and Siuhelem Rocha Silva and Belisa Maria Lopes Magalh{\~a}es and Aline C. C. Alencar and Andrea A. K{\"u}hn and Hernando A. del. Portillo and Carmen Fern{\'a}ndez-Becerra and Marcus Vin{\'i}cius Guimar{\~a}es de Lacerda},
  booktitle={PloS one},
  year={2014}
}
Molecular markers associated with the increase of chloroquine resistance and disease severity in Plasmodium vivax are needed. The objective of this study was to evaluate the expression levels of pvcrt-o and pvmdr-1 genes in a group of patients presenting CQRPv and patients who developed severe complications triggered exclusively by P. vivax infection. Two different sets of patients were included to this comprehensive study performed in the Brazilian Amazon: 1) patients with clinically… CONTINUE READING
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Single-Nucleotide Polymorphism and Copy Number Variation of the Multidrug Resistance-1 Locus of Plasmodium vivax: Local and Global Patterns

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