Expression, regulation and role of the MAGUK protein SAP-97 in human atrial myocardium.

  title={Expression, regulation and role of the MAGUK protein SAP-97 in human atrial myocardium.},
  author={David Godreau and Roger Vranckx and Ange Maguy and Catherine R{\"u}cker-Martin and Catherine Goyenvalle and Salah Abdelshafy and Sophie Tessier and Jean Paul Cou{\'e}til and St{\'e}phane Nicolas Hatem},
  journal={Cardiovascular research},
  volume={56 3},
OBJECTIVE In various cell types, membrane-associated guanylate kinases proteins called MAGUK play a major role in the spatial localization and clustering of ion channels. Here, we studied the expression and role of these anchoring proteins in human right atrial myocardium by means of various molecular, biochemical and physiological methods. METHODS AND RESULTS SAP-97, PSD-95, Chapsyn and SAP-102 messengers were detected by reverse transcriptase-polymerase chain reaction (RT-PCR) on mRNA… CONTINUE READING


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