Expression, regulation and function of human FcεRII (CD23) antigen
@article{Sarfati1992ExpressionRA, title={Expression, regulation and function of human Fc$\epsilon$RII (CD23) antigen}, author={Marika Sarfati and Sylvie Fournier and C. Y. Wu and Guy J. Delespesse}, journal={Immunologic Research}, year={1992}, volume={11}, pages={260-272} }
CD23, also known as the low affinity receptor for IgE (FcεRII), belongs to a novel superfamily of type-II integral membrane proteins. FcεRII expression was originally described on B cells but subsequent studies showed that CD23 is expressed on a variety of hematopoietic cells and is regulated by several cytokines (i.e., interleukin-4, interferons) in a tissue-specific manner. In some pathological conditions such as B-chronic lymphocytic leukemia, the CD23 gene is abnormally regulated resulting…
21 Citations
Soluble CD23 in allergic diseases.
- Medicine, BiologyArchivum immunologiae et therapiae experimentalis
- 1999
Serum level of sCD23 does not appear to be a hallmark of allergic diseases, however serum level of that molecule is significantly elevated in patients suffering from allergic disorders, and no correlation between s CD23 and IgE has been observed.
CD23 shedding: requirements for substrate recognition and inhibition by dipeptide hydroxamic acids
- Biology, ChemistryInflammation Research
- 2007
Both local sequence and distal domains have been shown to affect cleavage of CD23 and selective dipeptide hydroxamic acid inhibitors of CD 23 processing have been identified and demonstrated to very potently and selectively inhibit CD23 processing.
Comparative binding of soluble fragments (derCD23, sCD23, and exCD23) of recombinant human CD23 to CD21 (SCR 1-2) and native IgE, and their effect on IgE regulation.
- BiologyCellular immunology
- 2011
Soluble CD 23 in Allergic Diseases
- Medicine, Biology
- 2002
Serum levels of sCD23, a differentiation marker of B cells is identified with the low-affinity receptor for IgE, do not appear to be a hallmark of allergic diseases, however serum level of that molecule is significantly higher in patients suffering from allergic disorders, and no correlation between sCD 23 and IgE has been observed.
Regulation of CD23 isoforms on B-chronic lymphocytic leukemia.
- Biology, MedicineLeukemia research
- 2002
The CD23b promoter is a target for NF-AT transcription factors in B-CLL cells.
- BiologyBiochimica et biophysica acta
- 2002
Identification of new phosphorylation sites of CD23 in B-cells of patients with chronic lymphocytic leukemia.
- Biology, MedicineLeukemia research
- 2018
Retinoic acid inhibits CD40 plus IL-4 mediated IgE production through alterations of sCD23, sCD54 and IL-6 production
- Biology, MedicineInflammation Research
- 2004
ATRA interferes through several pathways with the anti-CD40 plus IL-4 mediated B cell activation, namely IL-6, CD23 and CD54, which results in inhibition of IgE production mediated by ATRA.
CD23 is recognized as tumor-associated antigen (TAA) in B-CLL by CD8+ autologous T lymphocytes.
- Biology, MedicineExperimental hematology
- 2007
In vitro release of soluble CD23 by human lymphocytes in ragweed-sensitive versus nonatopic patients following stimulation with ragweed antigen E.
- Medicine, BiologyAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
- 1996
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It is demonstrated that recombinant IL 2 also can up‐regulate CD23 expression on B cells, and results suggest that CD23 regulation is complex and related to the stage of activation and the cell type.
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IgE-immune complexes may regulate activation and differentiation of CD23-bearing surfaceIgM/surfaceIgD precursor B lymphocytes and inhibit IgM production by SAC and IL4-stimulated B cells.
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