Expression, regulation and function of human FcεRII (CD23) antigen

@article{Sarfati1992ExpressionRA,
  title={Expression, regulation and function of human Fc$\epsilon$RII (CD23) antigen},
  author={Marika Sarfati and Sylvie Fournier and C. Y. Wu and Guy J. Delespesse},
  journal={Immunologic Research},
  year={1992},
  volume={11},
  pages={260-272}
}
CD23, also known as the low affinity receptor for IgE (FcεRII), belongs to a novel superfamily of type-II integral membrane proteins. FcεRII expression was originally described on B cells but subsequent studies showed that CD23 is expressed on a variety of hematopoietic cells and is regulated by several cytokines (i.e., interleukin-4, interferons) in a tissue-specific manner. In some pathological conditions such as B-chronic lymphocytic leukemia, the CD23 gene is abnormally regulated resulting… 
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Soluble CD23 in allergic diseases.
TLDR
Serum level of sCD23 does not appear to be a hallmark of allergic diseases, however serum level of that molecule is significantly elevated in patients suffering from allergic disorders, and no correlation between s CD23 and IgE has been observed.
CD23 shedding: requirements for substrate recognition and inhibition by dipeptide hydroxamic acids
TLDR
Both local sequence and distal domains have been shown to affect cleavage of CD23 and selective dipeptide hydroxamic acid inhibitors of CD 23 processing have been identified and demonstrated to very potently and selectively inhibit CD23 processing.
Comparative binding of soluble fragments (derCD23, sCD23, and exCD23) of recombinant human CD23 to CD21 (SCR 1-2) and native IgE, and their effect on IgE regulation.
Soluble CD 23 in Allergic Diseases
TLDR
Serum levels of sCD23, a differentiation marker of B cells is identified with the low-affinity receptor for IgE, do not appear to be a hallmark of allergic diseases, however serum level of that molecule is significantly higher in patients suffering from allergic disorders, and no correlation between sCD 23 and IgE has been observed.
Regulation of CD23 isoforms on B-chronic lymphocytic leukemia.
The CD23b promoter is a target for NF-AT transcription factors in B-CLL cells.
Identification of new phosphorylation sites of CD23 in B-cells of patients with chronic lymphocytic leukemia.
Retinoic acid inhibits CD40 plus IL-4 mediated IgE production through alterations of sCD23, sCD54 and IL-6 production
TLDR
ATRA interferes through several pathways with the anti-CD40 plus IL-4 mediated B cell activation, namely IL-6, CD23 and CD54, which results in inhibition of IgE production mediated by ATRA.
CD23 is recognized as tumor-associated antigen (TAA) in B-CLL by CD8+ autologous T lymphocytes.
In vitro release of soluble CD23 by human lymphocytes in ragweed-sensitive versus nonatopic patients following stimulation with ragweed antigen E.
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References

SHOWING 1-10 OF 98 REFERENCES
Regulation by interleukin 2 of CD23 expression of leukemic and normal B cells: comparison with interleukin 4
TLDR
It is demonstrated that recombinant IL 2 also can up‐regulate CD23 expression on B cells, and results suggest that CD23 regulation is complex and related to the stage of activation and the cell type.
Two species of human Fcε receptor II ( FcεRII CD23 ): Tissue-specific and IL-4-specific regulation of gene expression
Expression of CD23 antigen and its regulation by IL-4 in chronic lymphocytic leukemia.
CD23 antigen regulation and signaling in chronic lymphocytic leukemia.
TLDR
It is concluded that the CD23 gene is abnormally regulated in B-CLL disease and that cross-linking of CD23 molecule delivers a negative growth signal to the leukemic B cells.
Allergen‐directed expression of Fc receptors for IgE (CD23) on human T lymphocytes is modulated by interleukin 4 and interferon‐γ
TLDR
It is reported that expression on T cells of the low‐affinity FcR for IgE (FcϵRII/CD23) is preferentially induced by stimulation with antigens that cause an IgE response.
Cross-linking of CD23 antigen by its natural ligand (IgE) or by anti-CD23 antibody prevents B lymphocyte proliferation and differentiation.
TLDR
IgE-immune complexes may regulate activation and differentiation of CD23-bearing surfaceIgM/surfaceIgD precursor B lymphocytes and inhibit IgM production by SAC and IL4-stimulated B cells.
Expression and functional role of CD23 on T cells
TLDR
It is demonstrated that CD23 is expressed on activated tonsil, but not peripheral blood T cells and plays a role, via the binding of CD23 mAb and CD23 material, present in EBVLCL andCD23 transfectant SN, in the regulation of T cell proliferation in response to mitogens such as PHA and TPA.
Possible role of human lymphocyte receptor for IgE (CD23) or its soluble fragments in the in vitro synthesis of human IgE.
TLDR
It is concluded that Fc epsilon R II or IgE-BF play an essential role both in the induction of IgE synthesis by normal B cells and in the ongoing IgE synthesisation by in vivo activated B cells from allergic donors.
Human recombinant interleukin 4 induces Fc epsilon R2/CD23 on normal human monocytes
TLDR
IFN-gamma was not able to inhibit the IL-4- induced expression of Fc epsilon R2/CD23 on Mo, neither when added to the culture together with IL- 4, nor when added 36 h earlier.
Human IgE-binding factors.
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