Expression, regulation, and activity of ABCA1 in human cell lines.

  title={Expression, regulation, and activity of ABCA1 in human cell lines.},
  author={M F Leal Denis and Rachel Bissonnette and Bassam Haidar and Larbi Krimbou and Michel Bouvier and Jacques J Genest},
  journal={Molecular genetics and metabolism},
  volume={78 4},
Mutations in the ATP-binding cassette transporter A1 (ABCA1) gene cause familial high-density lipoprotein deficiency and Tangier disease. ABCA1 plays a crucial role in active apolipoprotein A-I (apoA-I) lipidation, a key step in reverse cholesterol transport. We compared ABCA1 transcriptional regulation and cholesterol efflux in human skin fibroblasts, monocyte-derived macrophages and hepatocytes (HepG2). 8-Br-cAMP did not increase ABCA1 transcription in these tissues compared to mouse… CONTINUE READING
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