Expression, refolding, purification, molecular characterization, crystallization, and preliminary X-ray analysis of the receptor binding domain of human B7-2.

@article{Zhang2002ExpressionRP,
  title={Expression, refolding, purification, molecular characterization, crystallization, and preliminary X-ray analysis of the receptor binding domain of human B7-2.},
  author={Xuewu Zhang and J D Schwartz and Steven C. Almo and Stanley G. Nathenson},
  journal={Protein expression and purification},
  year={2002},
  volume={25 1},
  pages={105-13}
}
The cell-mediated immune response involves a series of specific molecular interactions between cell surface molecules on T cells and antigen-presenting cells. Of particular importance for the regulation of T cell activity is the interaction of the B7 isoforms, B7-1 and B7-2, with the T cell surface costimulatory receptors, CD28 and CTLA-4. The binding of CD28 by B7-1/B7-2 results in an enhancement of T cell responses initiated by the interaction between a clonotypic T cell receptor and its… CONTINUE READING
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