Expression, purification and enzymatic characterization of Brugia malayi dihydrofolate reductase.

Abstract

Brugia malayi (B. malayi) is one of the three causative agents of lymphatic filariasis, a neglected parasitic disease. Current literature suggests that dihydrofolate reductase is a potential drug target for the elimination of B. malayi. Here we report the recombinant expression and purification of a ∼20 kDa B. malayi dihydrofolate reductase (BmDHFR). A His6… (More)
DOI: 10.1016/j.pep.2016.08.012

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