Expression, purification and characterization of factor IX derivatives using a novel vector system.

@article{Yang2006ExpressionPA,
  title={Expression, purification and characterization of factor IX derivatives using a novel vector system.},
  author={Likui K. Yang and Kota Gopalakrishna and Chandrashekhara Manithody and Alireza R Rezaie},
  journal={Protein expression and purification},
  year={2006},
  volume={50 2},
  pages={
          196-202
        }
}
Recent studies have indicated that the loop harboring the S1 specificity site (residues 185-189 in chymotrypsin numbering) of coagulation proteases has several charged residues with important structural and functional roles for the catalytic activity of these proteases. This loop is allosterically linked to the Na(+)-binding site in both factor Xa and thrombin. There are three candidate residues (His-185, Glu-186, and Arg-188) on this loop of factor IXa (fIXa) whose side chains can influence… CONTINUE READING
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