Expression, purification and biochemical characterization of the N-terminal regions of human TIG3 and HRASLS3 proteins.

@article{Han2010ExpressionPA,
  title={Expression, purification and biochemical characterization of the N-terminal regions of human TIG3 and HRASLS3 proteins.},
  author={Byeong-Gu Han and Jea-Won Cho and Young-Doo Cho and Soo Youl Kim and Hye-jin Yoon and Hyun Kyu Song and H K Cheong and Young-Ho Jeon and Dong-ki Lee and Sangho Lee and Byung Il Lee},
  journal={Protein expression and purification},
  year={2010},
  volume={71 1},
  pages={103-7}
}
Tarzarotene-induced gene 3 (TIG3) and HRAS-like suppressor (HRASLS3) are members of the HREV107 family of class II tumor suppressors, which are down-regulated in various cancer cells. TIG3 and HRASLS3 also exhibit phospholipase activities. Both proteins share a common domain architecture with hydrophilic N-terminal and hydrophobic C-terminal regions. The hydrophobic C-terminal region is important for tumor suppression. However, the function of the hydrophilic N-terminal region remains elusive… CONTINUE READING