Expression, purification and assembly of soluble multimeric MHC class II-invariant chain complexes.

Abstract

Major histocompatibility class (MHC) II molecules are essential for running adaptive immune response. They are produced in the ER and targeted to late endosomes with the help of invariant chain (Ii) trimers. Ii trimerization may be induced by the Ii TM domain. To enable mechanistic and structural studies of MHC class II-Ii assembly, soluble forms of the… (More)
DOI: 10.1016/j.febslet.2012.03.038

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