Expression, microsomal and mitochondrial activities of cytochrome P450 enzymes in brain regions from control and phenobarbital-treated rabbits.

@article{Marini2007ExpressionMA,
  title={Expression, microsomal and mitochondrial activities of cytochrome P450 enzymes in brain regions from control and phenobarbital-treated rabbits.},
  author={Sandra Marini and Annalisa Nannelli and Daria Sodini and Stefania Dragoni and Massimo Valoti and Vincenzo Longo and Pier Giovanni Gervasi},
  journal={Life sciences},
  year={2007},
  volume={80 10},
  pages={910-7}
}
Expression and monooxygenase activity of various cytochrome P450 (CYP) enzymes along with constitutive androstane (CAR) and the pregnane X (PXR) receptors were investigated in the brain of control and phenobarbital-treated rabbits (80 mg/kg for 4 days). RT-PCR analysis, using specific primers, demonstrated that in control rabbits mRNAs of CYP 2A10, 2B4/5 and 3A6 were expressed, though to a different extent, in the liver, as well as in brain cortex, midbrain, cerebellum, striatum, hippocampus… CONTINUE READING
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