Expression, location, and interactions of ErbB2 and its intramembrane ligand Muc4 (sialomucin complex) in rat mammary gland during pregnancy.

@article{PriceSchiavi2005ExpressionLA,
  title={Expression, location, and interactions of ErbB2 and its intramembrane ligand Muc4 (sialomucin complex) in rat mammary gland during pregnancy.},
  author={Shari A. Price-Schiavi and Eran R Andrechek and Nebila Idris and Peter M.M.C. Li and Min Rong and Jin Zhang and Coralie A Carothers Carraway and William J. Muller and Kermit L. Iii Carraway},
  journal={Journal of cellular physiology},
  year={2005},
  volume={203 1},
  pages={
          44-53
        }
}
Muc4 (also called Sialomucin complex) is a heterodimeric glycoprotein complex consisting of a peripheral O-glycosylated subunit ASGP-1 (ascites sialoglycoprotein-1) tightly but non-covalently bound to an N-glycosylated transmembrane subunit ASGP-2. Muc4/SMC can act as an intramembrane ligand for ErbB2 via an EGF-like domain present in the transmembrane subunit. The complex is developmentally regulated in normal rat mammary gland and overexpressed in a number of mammary tumors. Overexpression of… CONTINUE READING
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