Expression, localization, and regulation of the neuregulin receptor ErbB3 in mouse heart.

Abstract

Neuregulins (NRG) belong to the EGF family of growth factors, which are ligands of the ErbB receptors. Their expression in the adult heart is essential, especially when the heart is submitted to cardiotoxic stress such as that produced by anthracyclines. It is considered that ErbB4 is the only NRG receptor expressed by the adult heart. Upon binding, ErbB4… (More)
DOI: 10.1002/jcp.22354

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