Expression, characterization, and genomic structure of carp JAK1 kinase gene.

@article{Chang1996ExpressionCA,
  title={Expression, characterization, and genomic structure of carp JAK1 kinase gene.},
  author={M. S. Chang and Garipelli Chang and J. H. Leu and Freesia L. Huang and Chen Kung Chou and Caroline J Huang and Tung Bin Lo},
  journal={DNA and cell biology},
  year={1996},
  volume={15 10},
  pages={827-44}
}
A 3.7-kb cDNA encodes the carp JAK1 kinase of 1,156 amino acid residues. The overall amino acid sequence identity between carp JAK1 and murine JAK1, JAK2, JAK3, and human TYK2 is 57%, 35.5%, 31.3%, and 42.4%, respectively. In addition, carp JAK1 shows higher sequence homology to mammalian JAK1 in both the kinase-like (JH2) and kinase (JH1) domains (approximately 70% identity). Therefore, carp JAK1 is a homolog of mammalian JAK1. To investigate the possible function of JH2 domain, full-length… CONTINUE READING

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