Expressing glomerular filtration rate in terms of extracellular fluid volume.

@article{Peters1992ExpressingGF,
  title={Expressing glomerular filtration rate in terms of extracellular fluid volume.},
  author={A Michael Peters},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={1992},
  volume={7 3},
  pages={205-10}
}
  • A Michael Peters
  • Published 1992 in
    Nephrology, dialysis, transplantation : official…
Glomerular filtration rate (GFR) is routinely calculated from the second exponential of the bi-exponential plasma clearance of filtration markers such as Cr-51 EDTA and Tc-99m DTPA. By ignoring the first exponential, true GFR is overestimated, an error which increases with increasing GFR. The rate constant, lambda 2, of the second exponential represents the rate at which glomerular filtration 'turns over' the extracellular fluid (ECF) and so closely approximates GFR/ECF volume. Again, the error… CONTINUE READING
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