Expressed human UGT1.4 protein catalyzes the formation of quaternary ammonium-linked glucuronides.

@article{Green1995ExpressedHU,
  title={Expressed human UGT1.4 protein catalyzes the formation of quaternary ammonium-linked glucuronides.},
  author={Melinda Green and Warren P. Bishop and Thomas R. Tephly},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1995},
  volume={23 3},
  pages={299-302}
}
In humans, the metabolism of a number of tertiary amine-containing pharmacological agents to quaternary ammonium-linked glucuronides, catalyzed by UDP-glucuronosyltransferase (UGT), represents a unique and important metabolic pathway for these compounds. A full-length cDNA-encoding human UGT1.4 (the so-called "minor" human bilirubin UGT) was inserted into the expression vector pREP9 and transfected into human embryonic kidney 293 cells, and stable transfectants were obtained after geneticin… CONTINUE READING

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