Expressed Pseudogenes in the Transcriptional Landscape of Human Cancers

@article{KalyanaSundaram2012ExpressedPI,
  title={Expressed Pseudogenes in the Transcriptional Landscape of Human Cancers},
  author={Shanker Kalyana-Sundaram and Chandan Kumar-Sinha and Sunita Shankar and D. R. T. Robinson and Yi-mi Wu and Xuhong Cao and Irfan Ahmed Asangani and Vishal Kothari and John R. Prensner and Robert J. Lonigro and Matthew K. Iyer and Terrence R. Barrette and Shanmugam Achiraman and Saravana M. Dhanasekaran and Nallasivam Palanisamy and Arul M. Chinnaiyan},
  journal={Cell},
  year={2012},
  volume={149},
  pages={1622-1634}
}
Pseudogene transcripts can provide a novel tier of gene regulation through generation of endogenous siRNAs or miRNA-binding sites. Characterization of pseudogene expression, however, has remained confined to anecdotal observations due to analytical challenges posed by the extremely close sequence similarity with their counterpart coding genes. Here, we describe a systematic analysis of pseudogene "transcription" from an RNA-Seq resource of 293 samples, representing 13 cancer and normal tissue… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 84 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 46 references

PseudoPipe: an automated pseudogene identification pipeline

Bioinformatics • 2006
View 6 Excerpts
Highly Influenced

BLAT--the BLAST-like alignment tool.

Genome research • 2002
View 4 Excerpts
Highly Influenced

A transcribed pseudogene of MYLK promotes cell proliferation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2011
View 4 Excerpts
Highly Influenced

Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

Y. Tay, L. Kats, +7 authors F Di Cunto
Cell 147, • 2011
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…