Expressed Pseudogenes in the Transcriptional Landscape of Human Cancers

  title={Expressed Pseudogenes in the Transcriptional Landscape of Human Cancers},
  author={Shanker Kalyana-Sundaram and Chandan Kumar-Sinha and Sunita Shankar and D. R. T. Robinson and Yi-mi Wu and Xuhong Cao and Irfan Ahmed Asangani and Vishal Kothari and John R. Prensner and Robert J. Lonigro and Matthew K. Iyer and Terrence R. Barrette and Shanmugam Achiraman and Saravana M. Dhanasekaran and Nallasivam Palanisamy and Arul M. Chinnaiyan},
Pseudogene transcripts can provide a novel tier of gene regulation through generation of endogenous siRNAs or miRNA-binding sites. Characterization of pseudogene expression, however, has remained confined to anecdotal observations due to analytical challenges posed by the extremely close sequence similarity with their counterpart coding genes. Here, we describe a systematic analysis of pseudogene "transcription" from an RNA-Seq resource of 293 samples, representing 13 cancer and normal tissue… CONTINUE READING


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