Expressed CYP4A4 metabolism of prostaglandin E(1) and arachidonic acid.

@article{Aitken2001ExpressedCM,
  title={Expressed CYP4A4 metabolism of prostaglandin E(1) and arachidonic acid.},
  author={A. Aitken and L. Roman and P. A. Loughran and M. de la Garza and B. Masters},
  journal={Archives of biochemistry and biophysics},
  year={2001},
  volume={393 2},
  pages={
          329-38
        }
}
Cytochrome P4504A4 (CYP4A4) is a hormonally induced pulmonary cytochrome P450 which metabolizes prostaglandins and arachidonic acid (AA) to their omega-hydroxylated products. Although the physiological function of this enzyme is unknown, prostaglandins play an important role in the regulation of reproductive, vascular, intestinal, and inflammatory systems and 20-hydroxyeicosatetraenoic acid, the omega-hydroxylated product of arachidonate, is a potent vasoconstrictor. Therefore, it is important… Expand
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***Reprinted with permission. No further reproduction is authorized without written permission from Elsevier. This version of the document is not the version of record. Figures and/or pictures may be missing from this format of the document.***
Xenobiotic metabolism in the tongue has received little attention in the literature. In the present study, we report a comparative analysis of constitutive cytochrome P450 (CYP) expression andExpand

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