Exposure to the Selective κ-Opioid Receptor Agonist Salvinorin A Modulates the Behavioral and Molecular Effects of Cocaine in Rats

@article{Chartoff2008ExposureTT,
  title={Exposure to the Selective κ-Opioid Receptor Agonist Salvinorin A Modulates the Behavioral and Molecular Effects of Cocaine in Rats},
  author={Elena H. Chartoff and David N. Potter and Diane Damez-Werno and Bruce M Cohen and William A Carlezon},
  journal={Neuropsychopharmacology},
  year={2008},
  volume={33},
  pages={2550-2550}
}
Stress and chronic exposure to drugs of abuse can trigger addictive and depressive disorders. Both stimuli increase activity of dynorphin, a neuropeptide that acts at κ-opioid receptors (KORs). In humans, KOR agonists cause dysphoria, raising the possibility that dynorphin modulates the depressive-like effects of stress and chronic drug use. We examined if KOR activation alters sensitivity to stimulant drugs by assessing the effects of the selective KOR agonist, salvinorin A (SalvA), on cocaine… CONTINUE READING
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