Exposure to schistosome eggs protects mice from TNBS-induced colitis.

  title={Exposure to schistosome eggs protects mice from TNBS-induced colitis.},
  author={David E. Elliott and Jie Li and Arthur Blum and Ahmed Metwali and Khurram Qadir and Joseph J. Urban and Joel V. Weinstock},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={284 3},
Crohn's disease results from dysregulated T helper (Th)1-type mucosal inflammation. Crohn's disease is rare in tropical countries but prevalent in developed countries with temperate climates, in which its incidence rose after 1940. In contrast, exposure to helminthic parasites is common in tropical countries but is rare in developed countries. Helminthic parasites induce immunomodulatory T cell responses in the host. We hypothesize that immunomodulatory responses due to helminths may attenuate… CONTINUE READING