Exposure to physical and psychological stressors elevates plasma interleukin 6: relationship to the activation of hypothalamic-pituitary-adrenal axis.

@article{Zhou1993ExposureTP,
  title={Exposure to physical and psychological stressors elevates plasma interleukin 6: relationship to the activation of hypothalamic-pituitary-adrenal axis.},
  author={D Zhou and Alexander W. Kusnecov and Michael R Shurin and M. Depaoli and Bruce S. Rabin},
  journal={Endocrinology},
  year={1993},
  volume={133 6},
  pages={
          2523-30
        }
}
  • D Zhou, Alexander W. Kusnecov, +2 authors Bruce S. Rabin
  • Published in Endocrinology 1993
  • Biology, Medicine
  • Interleukin 6 (IL-6) is a pleiotropic cytokine produced by the cells of immune and nonimmune origin. Increased production of IL-6 is associated with disturbances of homeostasis, such as trauma, sepsis, or inflammatory diseases. Endotoxemia, tissue injury, or immune inflammatory reactions as well as physical or psychological stress are known to cause increased production of IL-6. We have confirmed this by showing that rats exposed to electric footshock, physical restraint, or a conditioned… CONTINUE READING

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