Exposure to ornithine results in excessive accumulation of putrescine and apoptotic cell death in ornithine decarboxylase overproducing mouse myeloma cells.

@article{Tobias1995ExposureTO,
  title={Exposure to ornithine results in excessive accumulation of putrescine and apoptotic cell death in ornithine decarboxylase overproducing mouse myeloma cells.},
  author={K E Tobias and Chaim Kahana},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={1995},
  volume={6 10},
  pages={1279-85}
}
Ornithine decarboxylase (ODC) is the first key enzyme in the biosynthesis of polyamines, aliphatic polycations that are indispensable for the process of mammalian cell proliferation. The mouse myeloma cell line, 653-1, massively overproduces ODC due to the amplification of an active ODC gene. The addition of ornithine to the growth medium of 653-1 cells results in a massive increase in the intracellular concentration of putrescine, followed by rapid cell death. Ornithine-treated 653-1 cells… CONTINUE READING