Exposure to malondialdehyde induces an early redox unbalance preceding membrane toxicity in human erythrocytes.

@article{Tesoriere2002ExposureTM,
  title={Exposure to malondialdehyde induces an early redox unbalance preceding membrane toxicity in human erythrocytes.},
  author={Luisa Tesoriere and Daniele D'Arpa and Daniela Butera and Anna Maria Pintaudi and Mario Allegra and Maria Antonietta Livrea},
  journal={Free radical research},
  year={2002},
  volume={36 1},
  pages={
          89-97
        }
}
This work investigated the oxidative injury to human red blood cells (RBCs) by the exposure to exogenous malondialdehyde (MDA), in a physiological environment. When a 10% RBC suspension was incubated in autologous plasma, in the presence of 50 microM MDA, 30% of MDA entered into the cells. A time-course study showed that MDA caused early (30-120 min) and delayed (3-18 h) effects. MDA caused a fast depletion of reduced glutathione, and loss of the glucose-6-phosphate dehydrogenase activity… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS