Exposure to hydrogen peroxide induces cell death via apoptosis in cultured rat cortical neurons.

@article{Whittemore1994ExposureTH,
  title={Exposure to hydrogen peroxide induces cell death via apoptosis in cultured rat cortical neurons.},
  author={Edward R Whittemore and Deryk T. Loo and Carl Cotman},
  journal={Neuroreport},
  year={1994},
  volume={5 12},
  pages={1485-8}
}
To investigate whether direct oxidative damage may induce neuronal death via an apoptotic cell suicide pathway, we exposed cultured cortical neurons to the prooxidant hydrogen peroxide. Our experiments demonstrate that brief exposures to low concentrations of hydrogen peroxide can induce neuronal cell death via apoptosis as demonstrated by toxicity assays, specific DNA staining, and the appearance of DNA laddering on agarose gels. These results suggest that direct oxidative injury may serve as… CONTINUE READING

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