Exposure to chronic mild stress alters thresholds for lateral hypothalamic stimulation reward and subsequent responsiveness to amphetamine.

@article{Lin2002ExposureTC,
  title={Exposure to chronic mild stress alters thresholds for lateral hypothalamic stimulation reward and subsequent responsiveness to amphetamine.},
  author={Daniel W. Lin and Adie W. Bruijnzeel and Peter N. Schmidt and Athina Markou},
  journal={Neuroscience},
  year={2002},
  volume={114 4},
  pages={925-33}
}
Chronic mild stress in rodents has been proposed to model some of the environmental factors that contribute to the induction of depressive disorders in humans. This model is based on the hypothesis that chronic mild stress induces a change in brain reward function that resembles the symptomatology of major depression, namely, a decrease in responsiveness to rewarding stimuli. The purpose of the first experiment was to investigate whether chronic mild stress affects brain reward function as… CONTINUE READING

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