Exposure to bacterial DNA before hemorrhagic shock strongly aggravates systemic inflammation and gut barrier loss via an IFN-gamma-dependent route.

@article{Luyer2007ExposureTB,
  title={Exposure to bacterial DNA before hemorrhagic shock strongly aggravates systemic inflammation and gut barrier loss via an IFN-gamma-dependent route.},
  author={Misha D P Luyer and Wim A. Buurman and M'hamed Hadfoune and Tom F. W. Wolfs and Cornelis van't Veer and Jan A Jacobs and Cornelis H. C. Dejong and Jan Willem W. M. Greve},
  journal={Annals of surgery},
  year={2007},
  volume={245 5},
  pages={795-802}
}
OBJECTIVE To investigate the role of bacterial DNA in development of an excessive inflammatory response and loss of gut barrier loss following systemic hypotension. SUMMARY BACKGROUND DATA Bacterial infection may contribute to development of inflammatory complications following major surgery; however, the pathogenesis is not clear. A common denominator of bacterial infection is bacterial DNA characterized by unmethylated CpG motifs. Recently, it has been shown that bacterial DNA or synthetic… CONTINUE READING

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