Exposure to artemisinin at the trophozoite stage increases sexual conversion rates in the malaria parasite Plasmodium falciparum

@article{Portugaliza2020ExposureTA,
  title={Exposure to artemisinin at the trophozoite stage increases sexual conversion rates in the malaria parasite Plasmodium falciparum},
  author={H. P. Portugaliza and S. Miyazaki and Fiona J. A. Geurten and C. Pell and A. Rosanas-Urgell and C. Janse and Alfred Cort{\'e}s},
  journal={bioRxiv},
  year={2020}
}
Malaria transmission is dependent on formation of gametocytes in the human blood. The sexual conversion rate, the proportion of asexual parasites that convert into gametocytes at each multiplication cycle, is variable and reflects the relative parasite investment between transmission and maintaining the infection. The impact of environmental factors such as drugs on sexual conversion rates is not well understood. We developed a robust assay using gametocyte-reporter parasite lines to accurately… Expand
2 Citations
Single-Cell RNA Sequencing Reveals Cellular Heterogeneity and Stage Transition under Temperature Stress in Synchronized Plasmodium falciparum Cells
TLDR
In this study, it is found that parasites exhibit transcriptional heterogeneity in an otherwise morphologically synchronized culture, and a subset of parasites is continually committed to gametocytogenesis and stress-responsive pathways. Expand
Single-Cell RNA Sequencing Reveals Cellular Heterogeneity and Stage Transition under Temperature Stress in Synchronized <named-content content-type='genus-species'>Plasmodium falciparum</named-content> Cells
The malaria parasite has a complex life cycle exhibiting phenotypic and morphogenic variations in two different hosts by existing in heterogeneous developmental states. To investigate this cellularExpand

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