Exposure to acute stress induces brain interleukin-1beta protein in the rat.

@article{Nguyen1998ExposureTA,
  title={Exposure to acute stress induces brain interleukin-1beta protein in the rat.},
  author={Kien T. Nguyen and Terrence Deak and S Michael Owens and Takao Kohno and Monika Fleshner and Linda R. Watkins and Steven F. Maier},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1998},
  volume={18 6},
  pages={2239-46}
}
Peripheral immune stimulation such as that provided by lipopolysaccharide (LPS) has been reported to increase brain levels of IL-1beta mRNA, immunoreactivity, and bioactivity. Stressors produce many of the same neural and endocrine responses as those that follow LPS, but the impact of stressors on brain interleukin-1beta (IL-1beta) has not been systematically explored. An ELISA designed to detect IL-1beta was used to measure levels of IL-1beta protein in rat brain. Brain IL-1beta was explored… CONTINUE READING
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