Exposure to a lithium-paired context elicits gaping in rats: A model of anticipatory nausea.

@article{Limebeer2006ExposureTA,
  title={Exposure to a lithium-paired context elicits gaping in rats: A model of anticipatory nausea.},
  author={Cheryl L. Limebeer and Geoffrey Hall and Linda A Parker},
  journal={Physiology & behavior},
  year={2006},
  volume={88 4-5},
  pages={398-403}
}
Chemotherapy patients report anticipatory nausea and vomiting upon re-exposure to the cues previously associated with the treatment. Although rats do not vomit, they display a distinctive gaping reaction when exposed to a toxin-paired flavored solution. Here we report that rats also display gaping reactions during exposure to a context previously paired with the illness-inducing effects of lithium chloride (Experiment 1). This gaping reaction is suppressed by pretreatment with the antiemetic… CONTINUE READING

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