Exposure to Endotoxins during Sensitization Prevents Further Endotoxin-Induced Exacerbation of Airway Inflammation in a Mouse Model of Allergic Asthma

@article{DelayreOrthez2005ExposureTE,
  title={Exposure to Endotoxins during Sensitization Prevents Further Endotoxin-Induced Exacerbation of Airway Inflammation in a Mouse Model of Allergic Asthma},
  author={Carine Delayre-Orthez and Julien Becker and Fr{\'e}d{\'e}ric de Blay and Nelly Frossard and Françoise Pons},
  journal={International Archives of Allergy and Immunology},
  year={2005},
  volume={138},
  pages={298 - 304}
}
Background: We have shown previously that lipopolysaccharides (LPS) inhibited airway inflammation in allergen-sensitized and challenged mice when administered during sensitization, while exacerbating the inflammation when given upon challenge. We have here investigated the effect of LPS administered during both sensitization and challenge on airway inflammation, as well as on the profile of the T-helper (Th) response to allergen. Methods: Mice were sensitized and challenged with ovalbumin (OVA… Expand
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