Exposure to Endocrine Disruptor Induces Transgenerational Epigenetic Deregulation of MicroRNAs in Primordial Germ Cells

@inproceedings{BrieoEnrquez2015ExposureTE,
  title={Exposure to Endocrine Disruptor Induces Transgenerational Epigenetic Deregulation of MicroRNAs in Primordial Germ Cells},
  author={Miguel A Brie{\~n}o-Enr{\'i}quez and Jes{\'u}s Garc{\'i}a-L{\'o}pez and David B. C{\'a}rdenas and Sylvain Guibert and Elouan Cleroux and Luk{\'a}{\vs} Děd and Juan de Dios Hourcade and Jana Pěknicov{\'a} and Michael D Weber and Jes{\'u}s Del Mazo},
  booktitle={PloS one},
  year={2015}
}
In mammals, germ cell differentiation is initiated in the Primordial Germ Cells (PGCs) during fetal development. Prenatal exposure to environmental toxicants such as endocrine disruptors may alter PGC differentiation, development of the male germline and induce transgenerational epigenetic disorders. The anti-androgenic compound vinclozolin represents a paradigmatic example of molecule causing transgenerational effects on germ cells. We performed prenatal exposure to vinclozolin in mice and… CONTINUE READING
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