Exposure to Conspecific Alarm Chemosignals Alters Immune Responses in BALB/c Mice

  title={Exposure to Conspecific Alarm Chemosignals Alters Immune Responses in BALB/c Mice},
  author={R. Cocke and J. Moynihan and N. Cohen and L. Grota and R. Ader},
  journal={Brain, Behavior, and Immunity},
Male BALB/cJ mice were exposed for 24 h to odors from donor mice that were either footshocked or undisturbed. Mice exposed to odors from footshocked donors had suppressed splenic IL-2 production following in vitro concanavalin A (Con A) stimulation compared to home cage or apparatus controls. Stress odor exposure also resulted in reduced natural killer (NK) cell cytotoxicity against YAC-1 tumor target cells compared to controls. Stress odor exposure 24 h after intraperitoneal injection of… Expand
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