Exposure to Δ9-Tetrahydrocannabinol Impairs the Differentiation of Human Monocyte-derived Dendritic Cells and their Capacity for T cell Activation

Abstract

The capacity for human monocytes to differentiate into antigen-presenting dendritic cells (DC) can be influenced by a number of immune modulating signals. Monocytes express intracellular cannabinoid type 1 (CB1) and 2 (CB2) receptors and we demonstrate that exposure to Δ9-tetrahydrocannabinol (THC) inhibits the forskolin-induced generation of cyclic… (More)
DOI: 10.1007/s11481-015-9587-z

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@article{Roth2015ExposureT, title={Exposure to Δ9-Tetrahydrocannabinol Impairs the Differentiation of Human Monocyte-derived Dendritic Cells and their Capacity for T cell Activation}, author={Michael D Roth and Julie T. Castaneda and Sylvia M. Kiertscher}, journal={Journal of Neuroimmune Pharmacology}, year={2015}, volume={10}, pages={333-343} }