Exposure of the yeast Candida albicans to the anti‐neoplastic agent adriamycin increases the tolerance to amphotericin B

@article{OKeeffe2003ExposureOT,
  title={Exposure of the yeast Candida albicans to the anti‐neoplastic agent adriamycin increases the tolerance to amphotericin B},
  author={Joseph O'Keeffe and Sean Doyle and Kevin Kavanagh},
  journal={Journal of Pharmacy and Pharmacology},
  year={2003},
  volume={55}
}
Cancer patients experience a high incidence of fungal infections due to their immuno‐suppressed condition. This work has investigated the interaction of an anti‐neoplastic agent, adriamycin (doxorubicin), with the yeast Candida albicans and examined whether this drug altered the susceptibility of the yeast to amphotericin B – an anti‐fungal agent used for the treatment of systemic fungal infections in cancer patients. Exposure to adriamycin for 24 h increased the growth of C. albicans and… 
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This chapter has primarily focused into antimicrobial compounds developed through natural routes that are currently available as antibiotics for clinical uses and/or are at various developmental stages within the drug development pipeline for potential treatment of minor and life threatening infections.
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TLDR
It is found that micelles system could significantly improve the solubility of AMB yet reduce the overall toxicity, while the buccal tablet system is capable to suppress C. albicans biofilm formation.
Molecular simulation of a modified amphotericin B-Ergosterol artificial water channel to evaluate structure and water molecule transport performance
Abstract Molecular simulation was adopted to investigate and compare the water-channel performance of a common Amphotericin B_Ergosterol (AmBEr) model with that of two hydrophobically modified
An inexpensive and easy-to-make customized antibiotics mix for mycobacterium culture
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A customized antibiotics mix is presented that is easy to prepare at a fraction of the cost of the commercially available antibiotic mixture that protects against transient flora, which are normally present in lungs, without affecting mycobacterial colony number.

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