Exposure of phosphatidylserine by Xk-related protein family members during apoptosis.

@article{Suzuki2014ExposureOP,
  title={Exposure of phosphatidylserine by Xk-related protein family members during apoptosis.},
  author={Jun Suzuki and Eiichi Imanishi and Shigekazu Nagata},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 44},
  pages={30257-67}
}
Apoptotic cells expose phosphatidylserine (PtdSer) on their surface as an "eat me" signal. Mammalian Xk-related (Xkr) protein 8, which is predicted to contain six transmembrane regions, and its Caenorhabditis elegans homolog CED-8 promote apoptotic PtdSer exposure. The mouse and human Xkr families consist of eight and nine members, respectively. Here, we found that mouse Xkr family members, with the exception of Xkr2, are localized to the plasma membrane. When Xkr8-deficient cells, which do not… CONTINUE READING