Exposure of neonatal rats to anti-androgens induces penile mal-developments and infertility comparable to those induced by oestrogens.

@article{Simn2012ExposureON,
  title={Exposure of neonatal rats to anti-androgens induces penile mal-developments and infertility comparable to those induced by oestrogens.},
  author={Layla Sim{\'o}n and Leon Avery and Tim D. Braden and Carol s. Williams and Lilian A Okumu and John Jack W Williams and Hari Om Goyal},
  journal={International journal of andrology},
  year={2012},
  volume={35 3},
  pages={364-76}
}
We previously reported that oestrogen exposure in neonatal rats induced permanent infertility and malformed penis characterized by fat accumulation, which replaced most of the smooth muscle cells and cavernous spaces in the body of the penis, structures essential for erection. The objective of this study was to determine if reduced androgen production/action in the neonatal period, in the absence of exogenous oestrogen exposure, induces penile deformities similar to those caused by oestrogen… CONTINUE READING