Exposure of hepatocellular carcinoma cells to low-level As₂O₃‎ causes an extra toxicity pathway via L1 retrotransposition ‎induction.

@article{Karimi2014ExposureOH,
  title={Exposure of hepatocellular carcinoma cells to low-level As₂O₃‎ causes an extra toxicity pathway via L1 retrotransposition ‎induction.},
  author={Abbas Ali Karimi and Zahra Madjd and Laleh Koohi Habibi and Seyed Mohammad Akrami},
  journal={Toxicology letters},
  year={2014},
  volume={229 1},
  pages={111-7}
}
Various mechanisms have been proposed for toxicity and carcinogenesis pattern of arsenic, a naturally occurring metalloid. The extent to which the long interspersed element-1 (LINE-1) retrotransposon, an ubiquitous retroelement with autonomous mobility, can be influenced upon exposure to low-level arsenic remains to be elucidated. The aim of this study was to evaluate the possible effect of low-level As2O3 on L1 retrotransposition alteration in human hepatocellular carcinoma cells (HepG2). L1… CONTINUE READING