Exposure of foetal neural progenitor cells to IL-1β impairs their proliferation and alters their differentiation - a role for maternal inflammation?

@article{Crampton2012ExposureOF,
  title={Exposure of foetal neural progenitor cells to IL-1β impairs their proliferation and alters their differentiation - a role for maternal inflammation?},
  author={Sean J. Crampton and Louise M. Collins and Andr{\'e} Toulouse and Yvonne M Nolan and Gerard W O'Keeffe},
  journal={Journal of neurochemistry},
  year={2012},
  volume={120 6},
  pages={964-73}
}
During pregnancy, activation of the maternal immune system results in inflammation in the foetal nervous system. The causative agents are pro-inflammatory cytokines like interleukin-1β (IL-1β), produced by the foetus. In this study, we examine the effect of IL-1β on the proliferation and differentiation of neural progenitor cells (NPCs) to better understand its potential effects on the developing brain. We find that the IL-1β receptor (IL-1R1) is expressed in the ventral mesencephalon of the… CONTINUE READING

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