Exposure of fibrinogen receptor on human platelets by proteolytic enzymes.

  title={Exposure of fibrinogen receptor on human platelets by proteolytic enzymes.},
  author={Stefan Niewiarowski and Andrei Z. Budzynski and Thomas A Morinelli and T M Brudzynski and Graeme John Stewart},
  journal={The Journal of biological chemistry},
  volume={256 2},
Human platelets incubated with a-chymotrypsin or pronase did not aggregate with ADP or thrombin and did not agglutinate with ristocetin. On the other hand, they aggregated with fibrinogen even in the absence of platelet-activating compounds. This aggregation was not inhibited by prostaglandin El, sodium azide, or formaldehyde, indicating that it was independent of platelet metabolism. Calcium or magnesium were required for aggregation. Platelets preincubated with achymotrypsin or pronase also… CONTINUE READING


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