Exposure of atorvastatin is unchanged but lactone and acid metabolites are increased several‐fold in patients with atorvastatin‐induced myopathy

@article{Hermann2006ExposureOA,
  title={Exposure of atorvastatin is unchanged but lactone and acid metabolites are increased several‐fold in patients with atorvastatin‐induced myopathy},
  author={Monica Hermann and Martin Pr{\o}ven Bogsrud and Espen Molden and Anders Nikolai {\AA}sberg and Beata U. Mohebi and Leiv Ose and Kjetil Retterst{\o}l},
  journal={Clinical Pharmacology \& Therapeutics},
  year={2006},
  volume={79}
}
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133 Citations
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133 Citations

Guideline for SLCO 1 B 1 and Simvastatin-Induced Myopathy : 2014 Update
TLDR
Evidence from the literature supporting a single coding singlenucleotide polymorphism in SLCO1B1 increases systemic exposure to simvastatin and the risk of muscle toxicity and therapeutic recommendations are provided.
Effect of Cytochrome P450 3A5 Genotype on Atorvastatin Pharmacokinetics and Its Interaction with Clarithromycin
TLDR
To assess the effects of the cytochrome P450 (CYP) 3A genotype, CYP3A5, on atorvastatin pharmacokinetics and its interaction with clarithromycin.
Genetic determinants of statin-associated myopathy.
TLDR
Genome-wide studies suggest that there is a strong candidate variant within the SLCO1B1 gene (rs4149056) for statin-associated myopathy in a UK (European) population, and an enhanced understanding ofstatin-related myopathy may lead to safer drug development and use.
The potential of Atorvastatin for chronic lung diseases therapy
  • Alaa S. Tulbah
  • Chemistry
    Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
  • 2020
Atorvastatin Metabolite Measurements as a Diagnostic Tool for Statin-Induced Myopathy
TLDR
An altered metabolic pattern of atorvastatin in patients with SIM is confirmed and substantiates a central role of the lactone forms of statins in future investigations of statin myotoxicity.
Effects of SLCO1B1 and GATM gene variants on rosuvastatin-induced myopathy are unrelated to high plasma exposure of rosuvastatin and its metabolites
TLDR
SLCO1B1 and GATM genetic variants are potential biomarkers for predicting RST-induced myopathy, and their effects on SIM are unrelated to the high plasma exposure of RST and its metabolites.
Pharmacogenetics of Statin-Induced Myopathy: A Focused Review of the Clinical Translation of Pharmacokinetic Genetic Variants
TLDR
As the use of statins is extremely common and SIM continues to occur in a significant number of patients, future research investments in pharmacokinetic genetic variants have the potential to make a profound impact on public health.
Pharmacogenetics of Statin-Induced Myotoxicity
TLDR
This review provides an update on the genetic risk factors associated with statin-induced myotoxicity (SIM), and indicates that SIM is multifactorial.
Development of a Population Pharmacokinetic Model for Atorvastatin Acid and Its Lactone Metabolite
TLDR
A population pharmacokinetic model was developed and validated to describe atorvastatin acid and its lactone metabolite concentration-time data and it was demonstrated that the model adequately described the pharmacokinetics of both species.
Atorvastatin Pleiotropism: Role in Cardioprotection
TLDR
The present review article summarizes about the numerous pleiotropic effects exhibited by atorvastatin in affording cardioprotection.
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