Exposure of atorvastatin is unchanged but lactone and acid metabolites are increased several‐fold in patients with atorvastatin‐induced myopathy

@article{Hermann2006ExposureOA,
  title={Exposure of atorvastatin is unchanged but lactone and acid metabolites are increased several‐fold in patients with atorvastatin‐induced myopathy},
  author={M. Hermann and M. P. Bogsrud and E. Molden and A. {\AA}sberg and B. Mohebi and L. Ose and K. Retterst{\o}l},
  journal={Clinical Pharmacology & Therapeutics},
  year={2006},
  volume={79}
}
  • M. Hermann, M. P. Bogsrud, +4 authors K. Retterstøl
  • Published 2006
  • Medicine
  • Clinical Pharmacology & Therapeutics
  • The most serious side effect from statin treatment is myopathy, which may proceed to rhabdomyolysis. This is the first study to investigate whether the pharmacokinetics of either atorvastatin or its metabolites, or both, is altered in patients with atorvastatin‐related myopathy compared with healthy controls. 
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    References

    SHOWING 1-10 OF 34 REFERENCES
    Effect of itraconazole on the pharmacokinetics of atorvastatin
    • 324
    CYP3A5 Genotype has a Dose‐dependent Effect on ABT‐773 Plasma Levels
    • 47
    Statin‐associated myopathy
    • 589
    Pharmacokinetics of atorvastatin and its metabolites after single and multiple dosing in hypercholesterolaemic haemodialysis patients.
    • R. Lins, K. Matthys, +4 authors N. Lameire
    • Medicine
    • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
    • 2003
    • 106
    • PDF
    beta-Oxidation of simvastatin in mouse liver preparations.
    • 16
    Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization.
    • 317
    • PDF