• DOI:10.1016/j.clpt.2006.02.014
Corpus ID: 12838555

Exposure of atorvastatin is unchanged but lactone and acid metabolites are increased several‐fold in patients with atorvastatin‐induced myopathy

@article{Hermann2006ExposureOA,
  title={Exposure of atorvastatin is unchanged but lactone and acid metabolites are increased several‐fold in patients with atorvastatin‐induced myopathy},
  author={M. Hermann and M. P. Bogsrud and E. Molden and A. {\AA}sberg and B. Mohebi and L. Ose and K. Retterst{\o}l},
  journal={Clinical Pharmacology & Therapeutics},
  year={2006},
  volume={79}
}

M. Hermann, M. P. Bogsrud, +4 authors K. Retterstøl

Published 2006

Medicine

Clinical Pharmacology & Therapeutics

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ncbi.nlm.nih.gov

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The most serious side effect from statin treatment is myopathy, which may proceed to rhabdomyolysis. This is the first study to investigate whether the pharmacokinetics of either atorvastatin or its metabolites, or both, is altered in patients with atorvastatin‐related myopathy compared with healthy controls.