Exposure of atorvastatin is unchanged but lactone and acid metabolites are increased several‐fold in patients with atorvastatin‐induced myopathy

@article{Hermann2006ExposureOA,
  title={Exposure of atorvastatin is unchanged but lactone and acid metabolites are increased several‐fold in patients with atorvastatin‐induced myopathy},
  author={Monica Hermann and Martin Pr{\o}ven Bogsrud and Espen Molden and Anders Nikolai {\AA}sberg and Beata U. Mohebi and Leiv Ose and Kjetil Retterst{\o}l},
  journal={Clinical Pharmacology \& Therapeutics},
  year={2006},
  volume={79}
}
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Development of a Population Pharmacokinetic Model for Atorvastatin Acid and Its Lactone Metabolite
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A population pharmacokinetic model was developed and validated to describe atorvastatin acid and its lactone metabolite concentration-time data and it was demonstrated that the model adequately described the pharmacokinetics of both species.
Atorvastatin Pleiotropism: Role in Cardioprotection
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The present review article summarizes about the numerous pleiotropic effects exhibited by atorvastatin in affording cardioprotection.
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