Exposure of Plasmodium sporozoites to the intracellular concentration of potassium enhances infectivity and reduces cell passage activity.

@article{Kumar2007ExposureOP,
  title={Exposure of Plasmodium sporozoites to the intracellular concentration of potassium enhances infectivity and reduces cell passage activity.},
  author={Kota Arun Kumar and C{\'e}lia Regina da Silva Garcia and V. G. R. Chandran and Nico Van Rooijen and Yingyao Zhou and Elizabeth A. Winzeler and Victor Nussenzweig},
  journal={Molecular and biochemical parasitology},
  year={2007},
  volume={156 1},
  pages={32-40}
}
Malaria sporozoites migrate through several cells prior to a productive invasion that involves the formation of a parasitophorous vacuole (PV) where sporozoites undergo transformation into Exo-erythorcytic forms (EEFs). The precise mechanism leading to sporozoite activation for invasion is unknown, but prior traversal of host cells is required. During cell migration sporozoites are exposed to large shifts in K(+) concentration. We report here that incubation of sporozoites to the intracellular… CONTINUE READING

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