Exposure of Neonatal Rats to Parathion Elicits Sex-Selective Reprogramming of Metabolism and Alters the Response to a High-Fat Diet in Adulthood

@inproceedings{Lassiter2008ExposureON,
  title={Exposure of Neonatal Rats to Parathion Elicits Sex-Selective Reprogramming of Metabolism and Alters the Response to a High-Fat Diet in Adulthood},
  author={T. Leon Lassiter and Ian T. Ryde and Emiko A. Mackillop and Kathleen K. Brown and Edward D. Levin and Frederic J. Seidler and Theodore A. Slotkin},
  booktitle={Environmental health perspectives},
  year={2008}
}
BACKGROUND Developmental exposures to organophosphate pesticides are virtually ubiquitous. These agents are neurotoxicants, but recent evidence also points to lasting effects on metabolism. OBJECTIVES We administered parathion to neonatal rats. In adulthood, we assessed the impact on weight gain, food consumption, and glucose and lipid homeostasis, as well as the interaction with the effects of a high-fat diet. METHODS Neonatal rats were given parathion on postnatal days 1-4 using doses (0… CONTINUE READING
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Developmental exposure of rats to chlorpyrifos elicits sex - selective hyperlipidemia and hyperinsulinemia in adulthood

  • TA Slotkin, ED Levin, FJ Seidler
  • Environ Health Perspect
  • 2005
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