Exposure of K562 cells to anti-receptor monoclonal antibody OKT9 results in rapid redistribution and enhanced degradation of the transferrin receptor

@article{Weissman1986ExposureOK,
  title={Exposure of K562 cells to anti-receptor monoclonal antibody OKT9 results in rapid redistribution and enhanced degradation of the transferrin receptor},
  author={A. Weissman and R. Klausner and K. Rao and J. Harford},
  journal={The Journal of Cell Biology},
  year={1986},
  volume={102},
  pages={951 - 958}
}
  • A. Weissman, R. Klausner, +1 author J. Harford
  • Published 1986
  • Biology, Medicine
  • The Journal of Cell Biology
  • When the human erythroleukemia cell line K562 is treated with OKT9, a monoclonal antibody against the transferrin receptor, effects on receptor dynamics and degradation ensue. The apparent half-life of the receptor is decreased by greater than 50% as a result of OKT9 treatment. The transferrin receptor is also rapidly redistributed in response to OKT9 such that a lower percentage of the cellular receptors are displayed on the cell surface. OKT9 treatment also leads to a decrease in the total… CONTINUE READING
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