Exposure of Induced Pluripotent Stem Cell‐Derived Vascular Endothelial and Smooth Muscle Cells in Coculture to Hemodynamics Induces Primary Vascular Cell‐Like Phenotypes

@inproceedings{Collado2017ExposureOI,
  title={Exposure of Induced Pluripotent Stem Cell‐Derived Vascular Endothelial and Smooth Muscle Cells in Coculture to Hemodynamics Induces Primary Vascular Cell‐Like Phenotypes},
  author={Maria Sol Collado and Banumathi K Cole and Robert A. Figler and Mark J Lawson and David R. Manka and Michael B. Simmers and Steve Hoang and Felipe Serrano and Brett R. Blackman and Sanjay Sinha and Brian R. Wamhoff},
  booktitle={Stem cells translational medicine},
  year={2017}
}
Human induced pluripotent stem cells (iPSCs) can be differentiated into vascular endothelial (iEC) and smooth muscle (iSMC) cells. However, because iECs and iSMCs are not derived from an intact blood vessel, they represent an immature phenotype. Hemodynamics and heterotypic cell:cell communication play important roles in vascular cell phenotypic modulation. Here we tested the hypothesis that hemodynamic exposure of iECs in coculture with iSMCs induces an in vivo-like phenotype. iECs and iSMCs… CONTINUE READING

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