Exposure based waiving: the application of the toxicological threshold of concern (TTC) to inhalation exposure for aerosol ingredients in consumer products.

@article{Carthew2009ExposureBW,
  title={Exposure based waiving: the application of the toxicological threshold of concern (TTC) to inhalation exposure for aerosol ingredients in consumer products.},
  author={Philip Carthew and Caroline Clapp and Steve Gutsell},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2009},
  volume={47 6},
  pages={1287-95}
}
The inhalation toxicology studies available in the public domain have been reviewed to establish a database for inhalation toxicology and derive thresholds of toxicological concern (TTC) for effects in the respiratory tract and systemically for Cramer class 1 and 3 chemicals. These TTCs can be used as the basis for developing an exposure based waiving (EBW) approach to evaluating the potential for adverse effects from exposure to ingredients in aerosol products, used by consumers. The… CONTINUE READING
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