Exposure-Response Analyses Supporting Ticagrelor Dosing Recommendation in Patients With Prior Myocardial Infarction.

@article{Rshammar2017ExposureResponseAS,
  title={Exposure-Response Analyses Supporting Ticagrelor Dosing Recommendation in Patients With Prior Myocardial Infarction.},
  author={Daniel R{\"o}shammar and Joakim Nyberg and Tomas L G Andersson and Donald R. Stanski and Robert F. Storey and Bengt Hamr{\'e}n},
  journal={Journal of clinical pharmacology},
  year={2017},
  volume={57 5},
  pages={573-583}
}
The relationships between drug exposure and the composite risk of cardiovascular (CV) death, myocardial infarction (MI), and stroke as well as the risk of TIMI major bleeding were estimated following long-term treatment with ticagrelor 60 or 90 mg twice daily in 20,942 patients with prior MI. These analyses support the primary reported efficacy and safety… CONTINUE READING