Exposing the secrets of two well-known Lactobacillus casei phages, J-1 and PL-1, by genomic and structural analysis.

@article{Dieterle2014ExposingTS,
  title={Exposing the secrets of two well-known Lactobacillus casei phages, J-1 and PL-1, by genomic and structural analysis.},
  author={Mar{\'i}a Eugenia Dieterle and Charles A. Bowman and Carlos Batthyany and Esteban Lanzarotti and Adrian Gustavo Turjanski and Graham F. Hatfull and Mariana Piuri},
  journal={Applied and environmental microbiology},
  year={2014},
  volume={80 22},
  pages={7107-21}
}
Bacteriophage J-1 was isolated in 1965 from an abnormal fermentation of Yakult using Lactobacillus casei strain Shirota, and a related phage, PL-1, was subsequently recovered from a strain resistant to J-1. Complete genome sequencing shows that J-1 and PL-1 are almost identical, but PL-1 has a deletion of 1.9 kbp relative to J-1, resulting in the loss of four predicted gene products involved in immunity regulation. The structural proteins were identified by mass spectrometry analysis. Similarly… CONTINUE READING
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