Exposing malaria in-host diversity and estimating population diversity by capture-recapture using massively parallel pyrosequencing.

@article{Juliano2010ExposingMI,
  title={Exposing malaria in-host diversity and estimating population diversity by capture-recapture using massively parallel pyrosequencing.},
  author={Jonathan J. Juliano and Kimberly Marie Porter and Victor Mwapasa and Rithy Sem and William Oscar Rogers and Fr{\'e}d{\'e}ric Ariey and Chansuda Wongsrichanalai and A. Moutray Read and Steven Richard Meshnick},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 46},
  pages={
          20138-43
        }
}
Malaria infections commonly contain multiple genetically distinct variants. Mathematical and animal models suggest that interactions among these variants have a profound impact on the emergence of drug resistance. However, methods currently used for quantifying parasite diversity in individual infections are insensitive to low-abundance variants and are not quantitative for variant population sizes. To more completely describe the in-host complexity and ecology of malaria infections, we used… CONTINUE READING

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