Exporting RNA from the nucleus to the cytoplasm

@article{Khler2007ExportingRF,
  title={Exporting RNA from the nucleus to the cytoplasm},
  author={Alwin K{\"o}hler and Ed Hurt},
  journal={Nature Reviews Molecular Cell Biology},
  year={2007},
  volume={8},
  pages={761-773}
}
  • A. Köhler, E. Hurt
  • Published 2007
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
The transport of RNA molecules from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes via mobile export receptors. Small RNAs (such as tRNAs and microRNAs) follow relatively simple export routes by binding directly to export receptors. Large RNAs (such as ribosomal RNAs and mRNAs) assemble into complicated ribonucleoprotein (RNP) particles and recruit their exporters via… Expand
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References

SHOWING 1-10 OF 176 REFERENCES
Nuclear export of RNA
TLDR
This review summarizes studies performed over the last 15 years that led to the identification of cellular factors mediating nuclear export of the different classes of RNAs, including tRNAs, UsnRNAs), micro‐RNas, ribosomal RNAs and mRNAs. Expand
Transport between the cell nucleus and the cytoplasm.
TLDR
A focus of this review is nuclear export of messenger RNA, which apparently largely relies on export mediators distinct from importin beta-related factors. Expand
mRNA export: an assembly line from genes to nuclear pores.
TLDR
A newly identified link between the nuclear exosome and the transcription, 3'-end formation and export machineries suggests that early messenger ribonucleoprotein complex (mRNP) assembly is co-transcriptionally monitored, and nuclear retention of unspliced mRNAs by the perinuclear Mlp proteins reveals a novel mechanism of mRNP surveillance prior to export. Expand
Ratcheting mRNA out of the nucleus.
TLDR
In budding yeast, recent work suggests that the DEAD-box helicase DBP5 remodels mRNPs at the NPC cytoplasmic face by removing Mex67 and that the Dbp5 ATPase is activated by Gle1 and inositol hexaphosphate (IP(6)). Expand
Transport of messenger RNA from the nucleus to the cytoplasm.
All movement of molecules and macromolecules between the cytoplasm and the nucleus takes place through nuclear pore complexes (NPCs), very large macromolecular complexes that are the only channelsExpand
The interplay of nuclear mRNP assembly, mRNA surveillance and export.
TLDR
Understanding of the molecular mechanisms by which the heterodimeric receptor is recruited to cellular mRNAs indicates that the adaptors, together with additional proteins, are loaded cotranscriptionally to nascent m RNAs to form large ribonucleoprotein complexes (mRNPs). Expand
Identification of a tRNA-specific nuclear export receptor.
TLDR
RanGTP regulates the substrate-exportin-t interaction such that tRNA can be preferentially bound in the nucleus and released in the cytoplasm and RanGTP binds tRNA directly and with high affinity. Expand
Monomethylated cap structures facilitate RNA export from the nucleus
TLDR
Results suggest that the m7GpppN cap structure is likely to be a signal for RNA export from the nucleus, and that a mutant precursor mRNA unable to form detectable splicing complexes was significantly delayed by incorporation of a hypermethylated cap structure. Expand
Messenger RNAs are recruited for nuclear export during transcription.
TLDR
Evidence that mRNAs are targeted for nuclear export cotranscriptionally is presented and it is suggested that export factors are recruited to the sites of transcription to promote efficient mRNA export. Expand
Identification of a nuclear export receptor for tRNA
TLDR
The human protein Exportin(tRNA) has the functional properties expected of a transport receptor that mediates export of tRNA from the nucleus and in relief of the competitive inhibition of t RNA export caused by the introduction of saturating amounts of nuclear tRNA. Expand
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