Exportin-5 mediates nuclear export of minihelix-containing RNAs.

  title={Exportin-5 mediates nuclear export of minihelix-containing RNAs.},
  author={Carole Gwizdek and Batool Ossareh-Nazari and Amy M. Brownawell and Alain Doglio and Edouard Bertrand and Ian G. Macara and Catherine Dargemont},
  journal={The Journal of biological chemistry},
  volume={278 8},
The adenovirus VA1 RNA (VA1), a 160-nucleotide (nt)-long RNA transcribed by RNA polymerase III, is efficiently exported from the nucleus to the cytoplasm of infected cells, where it antagonizes the interferon-induced antiviral defense system. We recently reported that nuclear export of VA1 is mediated by a cis-acting RNA export motif, called minihelix, that comprises a double-stranded stem (>14 nt) with a base-paired 5' end and a 3-8-nt protruding 3' end. RNA export mediated by the minihelix… CONTINUE READING